Jonathan Peterson, PhD
Post Doctoral Fellowship - Physiology 2008-2012 (Johns Hopkins University)
Ph.D. - Exercise Physiology 2008 (West Virginia University School of Medicine)
M.S. - Exercise Physiology 2002 (University of Delaware)
B.S. - Sports Medicine 2000 (Messiah College, Grantham, PA)
Anatomy and Physiology
According to the National Health and Nutrition Examination Survey two-thirds of U.S. adults are either overweight or obese. The estimated direct costs associated with obesity, metabolic syndrome, and Type 2 Diabetes is approaching 100 billion dollars annually.
My research goals are to examine the changes in metabolism that occur in the presence of obesity and/or Type 2 Diabetes and to develop clinical biomarkers and potential therapeutic targets. Currently, my lab focuses on a family of secreted proteins termed C1q TNF-Related Proteins (CTRPs). CTRPs are a novel family of secreted proteins, which circulate in the blood stream. Many members of the CTRP family are adipokines, meaning secreted from adipose tissue, but the CTRP family includes proteins that are secreted from a variety of tissues. For example, CTRP15 (also called myonectin) is secreted primarily from skeletal muscle and therefore is called a myokine.
My research focuses on characterizing the functions of these proteins, using molecular, biochemical, in vitro and in vivo approaches. Much of my initial work demonstrates that the CTRP family of proteins contribute metabolism and are dysregulated with obesity. However, the functions of the CTRP protein family are still actively being investigated.
Research Projects or Grants
CTRP family of proteins as novel regulators of glucose and lipid metabolism
Molecular Mechanisms of CTRP3 Reduction on Lipid Accumulation in the Liver
Characterization of the CTRP family of proteins in lean compared with obese persons, feasibility of using CTRP?s as clinical biomarkers.
Seldin MM, Peterson JM, Byerly MS, Wei Z, Wong GW. Myonectin (CTRP15), a novel
myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem.
2012 Feb 17. [Epub ahead of print]
Wei Z, Peterson JM, Lei X, Cebotaru L, Wolfgang MJ, Baldeviano GC, Wong GW.
C1q/TNF-related protein-12 (CTRP12), a novel adipokine that improves insulin
sensitivity and glycemic control in mouse models of obesity and diabetes. J Biol
Chem. 2012 Jan 24.
Peterson JM, Aja S, Wei Z, Wong GW. CTRP1 protein enhances fatty acid
oxidation via AMP-activated protein kinase (AMPK) activation and acetyl-CoA
carboxylase (ACC) inhibition. J Biol Chem. 2012 Jan 6;287(2):1576-87.
Zheng Q, Yuan Y, Yi W, Lau WB, Wang Y, Wang X, Sun Y, Lopez BL, Christopher TA, Peterson JM, Wong GW, Yu S, Yi D, Ma XL. C1q/TNF-Related Proteins, A Family of Novel Adipokines, Induce Vascular Relaxation Through the Adiponectin Receptor-1/AMPK/eNOS/Nitric Oxide Signaling Pathway. Arterioscler Thromb Vasc Biol. 2011 Aug 11.
Kuhajda FP, Aja S, Tu Y, Han WF, El Meskini R, Landree LE, Peterson JM, Daniels K, Wong K, Wydysh EA, Townsend CA, Ronnett GV. Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity, and increases insulin sensitivity in diet-induced obesity. Am J Physiol Regul Integr Comp Physiol. 2011 Apr 13
Wei Z, Peterson JM, Wong GW. Metabolic regulation by C1q/TNF-related protein-13 (CTRP13): activation of AMP-activated protein kinase and suppression of fatty acid-induced JNK signaling. J Biol Chem. 2011 Mar 4.
Peterson JM , Wei Z, Wong GW. C1q/TNF-related protein-3 (CTRP3): a novel adipokine that regulates hepatic glucose output. J Biol Chem. 2010 Oct 15.
Deans MR, Peterson JM, Wong GW. Mammalian Otolin: A Multimeric Glycoprotein Specific to the Inner Ear that Interacts with Otoconial Matrix Protein Otoconin-90 and Cerebellin-1. PLoS One. 2010 Sep 15;5(9). pii: e12765.
Peterson JM , Wei Z, Wong GW. CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members. Biochem Biophys Res Commun. 2009 Oct 16;388(2):360-5.
Ip TY, Peterson J, Byrner R, Tou JC. Bone responses to body weight and moderate treadmill exercising in growing male obese (fa/fa) and lean Zucker rats. J Musculoskelet Neuronal Interact. 2009 Jul-Sep;9(3):155-66.
Peterson JM , Wang Y, Bryner R, Williamson DL, Alway SE. Bax signaling mediates palmitate-induced apoptosis in C2C12 myotubes. 2008 Am J Physiol Endocrinol Metab Dec;295(6):E1307-14.
Peterson JM , Bryner RW, Sindler A, Frisbee JC, Alway SE. Mitochondrial Apoptotic Signaling Is Elevated In Cardiac But Not Skeletal Muscle In The Obese Zucker Rat And Is Reduced With Aerobic Exercise. J Appl Physiol. 2008 Dec;105(6):1934-43.
Peterson JM , Bryner RW, Frisbee JC, Alway SE. Effects of exercise and obesity on UCP3 content in Rat hindlimb Muscles. Med Sci Sports Exerc. 2008 Sep;40(9):1616-22.
Peterson JM , Bryner RW, Alway SE. Satellite cell proliferation is reduced in muscles of obese Zucker rats but restored with loading. Am J Physiol Cell Physiol. 2008 Aug;295(2):C521-8.
Peterson JM and Wong GW. (2011). CTRPs as Adipokines. In Preedy VR, Hunater RJ (Eds.), Adipokines (pp. 52-59). Enfield, NH: Science Publishers.
Peterson JM and Wong GW. (2012). CTRPs: Novel Adipokines. In Licker M, Weil J, Blumel D, Malmoli S, Maybaum H, Wagner C, & Taylor R (Eds.), Yearbook of Science & Technology (pp. 50-52). New York: McGraw-Hill.
Hiking/camping, vegetable gardening, Pittsburgh Steelers.