Kesheng Wang

Kesheng Wang
Assistant Professor, Department of Biostatistics and Epidemiology
Phone: 423-439-4481
Email: Office: Lamb Hall, room 46C (G-1 level)
Mailing: Box 70259
           Johnson City, TN 37614


Education

Postdoctoral Fellow in Statistical Genetics/Genetic Epidemiology, The Hospital for Sick Children / University of Toronto, Canada (2002-2006).

Ph.D. in Population Genetics and Biostatistics, University of Goettingen, Goettingen, Germany (1997-2001).

M.S. in Biostatistics and Quantitative Genetics, China Agricultural University, Beijing, PR China (1989-1992).

B.S. in Biology, Henan Normal University, Xinxiang, PR China (1985-1989)


Courses Taught

PUBH 5350 - Biostatistics II
PUBH 5480 - Genetic Epidemiology
PUBH 6410 - Advanced Multivariate Analysis
BIOC 6600 - Molecular Biology and Genomics

Research Focus
  • Biostatistics, Chronic Disease Epidemiology and Psychiatric Epidemiology
  • Genetic Epidemiology, Population Genetics and Quantitative Genetics

Current Research Topics

1. Dietary patterns, smoking behavior, lifestyle and genetic risk factors of cancer

2. Genetic and environmental factors influencing obesity and type 2 diabetes

3. Genetic analyses of alcohol dependence and alcohol-related phenotypes

4. Gene x environment interactions in psychiatric disorders (ADHD, bipolar disorder, major depression, schizophrenia) 

5. Immune system in the pathogenesis of HCV infection

6. Statistical analysis of clinical trial and large epidemiology data

Research Projects (2009-present)

1. Wang KS (Co-I). Tim-3-mediated IL-12 dysregulation in antiviral response to HCV infection. NIH R01, 2011-2016.

2. Wang KS (PI). Gender differences and parental influence in genetic association analysis of alcohol dependence in the COGA sample. RDC, 2010.

3. Wang KS (Co-I). Impact of clinic decision on the rapidity of blood pressure goal attainment. RDC, 2009.


Selected Publications (2005-present)

1. Aragam NR, Wang KS, Anderson JL, Liu XF (2012) TMPRSS9 and GRIN2B are associated with neuroticism: a genome-wide association study in a European sample. Journal of Psychiatric Research (under review).

2. Wang KS,  Liu XL,  Zheng S, Zeng M, Pan Y, Callahan K (2012)  A novel locus for body mass index on 5p15.2: a meta-analysis of two genome-wide association studies. Gene (under review)

3. Xu C, Wang KS, Kennedy JL, Hughes B, Cooke RG, Parikh SV, Warsh JJ (2012) Bipolar disorder: evidence of an interaction with calcium signalling genes, TRPM2 and iPLA2 on the disease risk. Psychiatry Genetics (under review).

4. Wang KS, Zhang Q, Liu XF, Wu LY, Zeng M (2012) PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies. Schizophrenia Research (under review).

5. Moorman JP, Wang JM, Zhang Y, Ji XJ, Ma CJ, Wu XY, Jia ZS, Wang KS, Niki T, Hirashima M, Yao ZQ (2012) Tim-3/Gal-9 interaction shifts the balance of regulatory and effector T cells in HCV infection. Blood (under review). 

6. Wang KS, Liu XF, Zhang Q, Zeng M (2012) ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies with replication in a family-based sample. Drug and Alcohol Dependence (under revision).

7. Wang KS, Liu XF, Zhang Q, Wu LY, Zeng M (2011) Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms. Journal of Neural Transmission. (Epub ahead of print: available November 11, 2011).

8. Wang KS,  Liu XF,  Aragam NR, Jian XQ, Mullersman JE, Liu YL, Pan Y (2011). Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence. Journal of Molecular Neuroscience. (Epub ahead of print: available May 6, 2011).

9. Wang KS, Liu XF, Zhang QY, Aragam NR, Pan Y. Parent-of-origin effects of FAS and PDLIM1 in attention-deficit hyperactivity disorder. Journal of Psychiatry and Neuroscience. 2012; 37(1): 46-52.

10. Wang KS, Liu XF, Zhang QY, Pan Y, Aragam NR, Zeng M. Meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence. Journal of Psychiatric Research. 2011; 45(11): 1419-25.

11. Wang KS,  Liu XF,  Aragam NR, Jian XQ, Mullersman JE, Liu YL, Pan Y. Family-based association analysis of alcohol dependence in the COGA sample and replication in the Australian twin-family study. Journal of Neural Transmission. 2011; 118(9):1293-1299.

12. Liu XF, Wang KS, Lee K. Association of standardized estimated glomerular filtration rate   with the prevalence of hypertension among adults in the United States. Journal of Human Hypertension. 2011; 25(8):469-475.

13. Jian XQ, Wang KS, Wu TJ, Hillhouse JJ and Mullersman JE. Association of ADAM10 and CAMK2A polymorphisms with conduct disorder in the COGA sample: evidence from family-based studies. Journal of Abnormal Child Psychology. 2011; 39(6):773-782.

14. Wang KS, Liu XF, Zhang QY, Aragam NR, Pan Y. Genome-wide association analysis of age at onset in schizophrenia in a European-American sample. American Journal of Medical Genetics. Part B Neurophychiatric Genetics. 2011; 156(6): 671-680.

15. Aragam NR, Wang KS, Pan Y. Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples. Journal of Affective Disorder. 2011; 133(3): 516-521.

16. Pan Y, Wang KS. Spousal concordance in academic achievements and IQ: A principal component analysis. Open Journal of Psychiatry. 2011; 1(2):15-19.

17. Pan Y, Wang KS, Aragam N. NTM and NR3C2 polymorphisms influencing intelligence: family-based association studies. Prog Neuropsychopharmacol Biol Psychiatry. 2011; 35(1): 154-160.

18. Wang KS, Liu XF, Aragam N. A genome-wide meta-analysis identifies loci associated with schizophrenia and bipolar disorder. Schizophrenia Research. 2010; 124(1-3):192-9.

19. Wang KS, Mullersman JE, Liu XF. Family-based association analysis of MAPT gene in Parkinson disease. Journal of Applied Genetics. 2010; 51(4):509-14.

20. Wu LY, Chipman HA, Bull S, Briollais L, Wang KS. A Bayesian segmentation approach to ascertain copy-number variations at the population level. Bioinformatics. 2009; 25(13):1669-1679.

21. Walker EJ, Hirschfield GM, Xu C, Lu Y, Liu X, Coltescu C, Wang KS, Newman WG, Bykerk V, Keystone E, Amos CI, Heathcote EJ and Siminovitch KA. CTLA-4/ICOS gene variants and haplotypes are associated with rheumatoid arthritis and primary biliary cirrhosis in the Canadian population. Arthritis & Rheumatism. 2009; 60(4): 931-937.

22. Wallis RH, Wang KS (co-first author), Dabrowski D, Marandi L, Ning T, Murphy T, Hsieh E, Paterson AD, Poussier P. Type 1 diabetes in the BB rat: a polygenic disease. Diabetes. 2009; 58(4): 1007-1017.

23. Xu C, Li PP, Cook RG, Parikh SV, Wang KS, Kennedy JL, Warsh JJ. TRPM2 variants and bipolar disorder risk: confirmation in a family-based association. Biploar Disorder. 2009; 11(1): 1-10.

24. Wallis RH, Wang KS, Dabrowski D, Marandi L, Ning T, Murphy T, Hsieh E, Paterson AD, Poussier P. A novel type 1 diabetes susceptibility locus on rat chromosome 8 affects spontaneous but not experimentally-induced disease. Diabetes. 2007; 56(6):1731-1736.

25. Beyene J, Tritchler D, Bull SB, Cartier KC, Jonasdottir G, Kraja AT, Li N, Nock NL, Parkhomenko E, Rao JS, Stein CM, Sutradhar R, Waaijenborg S, Wang KS, Wang Y, Wolkow P. Multivariate analysis of complex gene expression and clinical phenotypes with genetic marker data. Genet Epidemiology. 2007; 31 Suppl 1:S103-109. 

26. Culverhouse RC, Suarez BK, Beckmann L, Chen P, Chen YS, Chiu YF, Chang-Claude J, Dempfle A, Hein R, Kazma R, Lebrec JJ, Lee S, Lim S, Maher BS, Park T, Perdry H, Wang KS, Wolkow PP, Xu W. Gene by environment interactions. Genet Epidemiology. 2007; 31 Suppl 1:S68-74.

27. Liu XQ, Greenwood C, Wang KS, Paterson AD. A genome scan for parent-of-origin linkage effects in alcoholism. BMC Genetics. 2005; 4:S160.

28. Wang KS, Liu M, Paterson AD. Evaluating outlier loci and their effect on the identification of pedigree errors. BMC Genetics. 2005; 4:S155.

Conference Abstracts (2004-present)

1. Wang KS, Liu XF, Pan Y, Aragam N, Zeng M (2011) FSTL4 and SEMA5A are associated with alcohol dependence: meta-analysis of two genome-wide association studies. 139th APHA Annual Meeting, Washington DC. A235463.

2. Zhang Q, Wang K, Province MA, Borecki I (2011) Identifying rare variants with heterogeneous effects from pooled sequencing data. ASHG 61th Annual Meeting, Montreal, Canada. 633F.

3. Wang KS, Liu X, Aragam NR (2010) A Genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. ASHG 60th Annual Meeting, Washington DC. A2650.

4. Aragam NR and Wang KS (2010) Genome-wide association analysis of gender difference in major depressive disorder in the Netherlands population sample from NESDA and NTR registries.  ASHG 60th Annual Meeting, Washington DC. A2621

5. Aragam NR and Wang KS (2010) Genome-wide association analysis of gene x gender interaction of neuroticism in the Netherlands population sample from NESDA and NTR registries. Genetic Epidemiology. 34(8):934. IGES 19th Annual Meeting, Boston. 

6. Liu XF, Liu M and Wang KS (2010) Latent variable models for development of composite indices. 2010 Spring meeting, the Eastern North American Region of the International Biometric Society (IBS).  New Orleans, Louisiana.

7. Gong S, Wu T, Liu XF, Wang KS (2010) Family income, maternal marital status and employment, and the development of obesity during childhood. APHA 138th Annual Meeting, Denver, CO. A223653.

8. Wang KS, Liu XF, Aragam N, Jian XQ, Mullersman JE (2009) Family-based association studies of alcohol dependence and age at onset in the COGA sample. APHA 137th Annual Meeting, Philadelphia, PA. A201530.

9. Wang KS, Wu LY, Liu M (2007) Evaluating marker-based pairwise relatedness estimators for population-based genome-wide association study. ASHG 57th Annual Meeting, San Diego. A2078.

10. Wu LY, Wang KS (2007) A Bayesian chromosome peeling algorithm to detect genomic DNA copy number variations in array CGH data. ASHG 57th Annual Meeting, San Diego. A2510.

11. Wang KS, Liu M, Bharaj B, Chen HT,  Curtis JA, Newhook LA, Paterson AD M (2006) Significant association of vitamin D receptor (VDR) haplotypes with early onset type 1 diabetes in Newfoundland. ASHG 56th Annual Meeting, New Orleans. A1684.

12. Wang KS, Liu M, Bharaj B, Lu M, Chen HT,  Curtis JA, Newhook LA, Paterson AD (2005) Allelic and haplotypic association of NOS2A with type 1 diabetes in Newfoundland. ASHG 55th Annual Meeting, Salt Lake City. A1853.

13. Wang KS, Liu M, Bharaj B, Lu M, Chen HT, Curtis JA, Newhook LA, Paterson AD (2005) Association of CTLA4 gene polymorphisms with age at diagnosis of type 1 diabetes in Newfoundland: a family-based study. Genetic Epidemiology. 29(3):284. IGES 14th Annual Meeting, Park City.

14. Wang KS, Liu M, Bharaj B, Lu M, Chen HT, Curtis JA, Newhook LA, Paterson AD (2004) Family based association study between BCL2 gene and type 1 diabetes in Newfoundland. Genetic Epidemiology. 27(3):302. IGES 13th Annual Meeting, The Netherlands.

15. Liu M, Wang KS, Bharaj B, Lu M, Chen HT, Curtis JA, Newhook LA, Paterson AD (2004) Association of the polymorphisms of the IGF2-INS-TH gene cluster with susceptibility to type 1 diabetes. Genetic Epidemiology. 27(3):283-284. IGES 13th Annual Meeting, The Netherlands.

16. Wang KS, Liu M, Bharaj B, Lu M, Chen HT,  Curtis JA, Newhook LA, Paterson AD (2004) Significant association between PTPN22 gene polymorphisms and type 1 diabetes in Newfoundland. ASHG 54th Annual Meeting, Toronto. A2194.

Selected Presentations (2002-present)

1. Wang KS(January, 2012) Binary outcomes and statistical analysis. 2012 Faculty Development Day Enhancing faculty participation in research and teaching, ETSU.

2. Wang KS (November, 2011) FSTL4 and SEMA5A are associated with alcohol dependence: meta-analysis of two genome-wide association studies. 139th APHA Annual Meeting, Washington DC.

3. Wang KS (February, 2011) Genome-wide association study of alcohol dependence: a meta-analysis. COPH Grand Rounds, ETSU.

4. Wang KS (April, 2010) Meta-analysis of genome-wide association data identifies novel loci for age at onset in Parkinson disease. Seminar at The Institute for Quantitative Biology, ETSU.

5. Wang KS (November, 2009) Family-based association studies of alcohol dependence and age at onset in the COGA sample. APHA 137th Annual Meeting, Philidephia, PA, USA.

6. Wang KS (October, 2009) Genetic association studies of alcohol dependence and age at onset. MTSU, Murfreesboro, TN.

7. Wang KS (Sept, 2009) A family-based genome-wide association study of alcohol dependence and related personality traits. 6th Annual Primary Care and Prevention Research Day, ETSU, Johnson City, TN.

8. Wang KS (June, 2008) QTL mapping in animal model ? a tutorial. The Centre for Applied Genomics, The Hospital for Sick Children, Toronto.

9. Wang KS (May, 2008) Multivariate linkage analysis of immune phenotypes related to rodent type 1 diabetes. Genome Canada Group Scientific Meeting, Hamilton.

10. Wang KS (March, 2008) Linkage and association studies in type 1 diabetes. University of Calgary, Calgary.

11. Wang KS (September, 2007) Genetic association studies of type 1 diabetes: a model for complex diseases. McMaster University, Hamilton. 

12. Wang KS (May, 2007) Association study of age of diagnosis of type 1 diabetes in 4 samples: nonparametric methods. Genome Canada Annual Project Retreat, King City.

13. Wang KS (January, 2007) Association study of age of diagnosis of type 1 diabetes using Illumina candidate gene panel. Genome Canada Group Scientific Meeting, Toronto.

14. Wang KS (November, 2006) Presented the paper ?Principal components analysis corrects for stratification in genome-wide association studies? by Price et al. (Nature Genetics 38, 904 ? 909, 2006). Canadian Videoconference: Genetic Epidemiology Journal Club, Toronto.

15. Wang KS (November, 2006) Population stratification in genome-wide association studies. Research Seminar and Journal Club: Statistical Methods for Genomics. Mount Sinai Hospital, Toronto.

16. Wang KS (April, 2006) Mapping quantitative trait loci (QTL) for complex traits in experimental crosses. Genome Canada Group Scientific Meeting, Toronto.

17. Wang KS (October, 2005) Linkage disequilibrium mapping of age at onset of type 1 diabetes in Newfoundland. Genome Canada Group Scientific Retreat, Toronto.

18. Wang KS (August, 2004) Association of CD1 and PTPN22 polymorphisms with type 1 diabetes in Newfoundland. Genome Canada Group Scientific Meeting, Toronto.

19. Wang KS (November, 2003) Polymorphisms of BCL2 and CTLA4 are associated with type 1 diabetes in Newfoundland. Genome Canada Group Scientific Retreat, Toronto.

20. Wang KS (March, 2003) Linkage disequilibrium and haplotype mapping. Research Seminar and Journal Club: Statistical Methods in Human Genetics Research. Mount Sinai Hospital, Toronto.

21. Wang KS (December, 2002) Methods of QTL mapping in experimental population. Research Seminar: Statistical Analysis of Molecular Data. China Agricultural University, Beijing.

22. Wang KS (November, 2002) Basic approaches of QTL mapping in animal model. Research Seminar and Journal Club: Statistical Methods in Human Genetics Research. Mount Sinai Hospital, Toronto.


Personal Interests

Reading, Traveling, Taiji