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Additional Contact Information: Michelle Chandley, PhD MPH Department of Biomedical Sciences |
EDUCATIONAL/PROFESSIONAL EXPERIENCE
B.S. Biology, Mars Hill University, 1995
PhD Biomedical Sciences, Quillen College of Medicine, East Tennessee State University,
2008
MPH Health Services Management and Policy, College of Public Health, East Tennessee
State University, 2015
RESEACH/TEACHING INTERESTS
1- Neuropathology and neuroinflammation associated with psychiatric disorders
2- Human Anatomy and Neuroanatomy
3- Role of glia in neural plasticity
The focus of my laboratory research is to identify molecular markers and neuropathological changes using postmortem human brain tissue in donors affected with psychiatric disorders when compared to undiagnosed brain donors. My primary interest is to determine if a unique cell-specific pathology is associated with autism, depression and suicide. In addition to human studies, my research has expanded to include the use of animals to determine if the human findings can be recapitulated in animal models that demonstrate behaviors that are associated with these disorders. These studies are vital in determining future translational studies that improve therapies or identify preventative measures in autism and depression.
My overarching goal for teaching in courses in the Biomedical Sciences Department is to facilitate the application of learned skills and concepts in human anatomy, scientific communication and neuroscience that will forever aid students in their chosen pathway in healthcare. My aims for supporting the stated teaching goal are to 1) continually evaluate rehabilitative, medical and graduate educational strategies and technology, 2) reach out to students for feedback and 3) establish avenues to incorporate clinical applications and research findings routinely.
LABORATORY PERSONNELL
Gethein Andrew (Master’s Student, Biomedical Sciences, ETSU)
Emma Self (undergraduate, Health Sciences, ETSU)
Hannah Martin (undergraduate, University Honor’s Student, ETSU)
ACTIVE RESEARCH FUNDING
NIH MH119628 “Neuroinflammatory mediators of glutamatergic & GABAergic neuropathology in the anterior cingulate cortex of autism spectrum disorder (ASD)”
NIH MH 114161 “Oxidative damage and base excision repair in white matter oligodendrocytes in major depressive disorder”
ETSU funding
Link to the Complete List of Published Work in My Bibliography
SELECTED PUBLICATIONS
1. Sciara, A.N., Beasley, B., Crawford, J.D., Anderson, E.P., Carrasco, T., Zheng, S., Ordway, G.A., and Chandley, M.J. Neuroinflammatory gene expression alterations in anterior cingulate cortical white and gray matter in males with autism spectrum disorder. Autism Res. June;13(6). 870-884 (2020)
2. Ordway G.A., Szebeni A., Hernandez L.J., Crawford J.D., Szebeni K., Chandley M.J., Burgess K.C. Miller C., Bakkalbasi E. and Brown R.W. “Antidepressant-like actions of inhibitors of poly(ADP-ribose) polymerase in rodent models.” Int. J. Neuropsychopharmacol. December 1;20(12). 994-1004 (2017)
3. Szebeni A, Szebeni K, DiPeri TP, Johnson LA, Stockmeier CA, Crawford JD, Chandley MJ, Hernandez LJ, Burgess KC, Brown RW, and Ordway GA. Elevated DNA oxidation and DNA repair enzyme expression in brain white matter in major depressive disorder. International journal of neuropsychopharmacology May 1; 20(5). (2017)
4. Chandley MJ, Crawford JD, Szebeni K, Szebeni A, and Ordway GA. NTRK2 expression levels are reduced in laser captured pyramidal neurons from the anterior cingulate cortex of males with autism spectrum disorder. Molecular Autism May;6(28). (2015).
5. Crawford JD, Chandley MJ, Szebeni K, Szebeni A, Waters B, and Ordway GA. "Elevated GFAP protein in anterior cingulate cortical white matter in males with autism spectrum disorder." Autism Research Apr;6. (2015).
6. Chandley MJ, Szebeni A, Szebeni K, Crawford JD, Stockmeier CA, Turecki G, Kostrzewa RM, and Ordway GA. Elevated gene expression of glutamate receptors in noradrenergic neurons from the locus coeruleus in major depression. Int J of Neuropsychopharmacol, Oct;17(10):1569-78. (2014)
7. Szebeni A, Szebeni K, DiPeri T, Chandley MJ, Crawford JD, Stockmeier CA, & Ordway GA. Shortened telomere length in white matter oligodendrocytes in major depression: potential role of oxidative stress. Int J of Neuropsychopharmacol, Oct;17(10):1579-89. (2014)
BOOK CHAPTERS
1. Chandley MJ and Ordway GA. The Noradrenergic System in Depression and Suicide. In: A Concise Guide to Understanding Suicide: Epidemiology, Pathophysiology, and Prevention. (eds. Koslow, Nemeroff, and Ruiz) Cambridge University Press, Cambridge. (2014)