|
Additional Contact Information: Department of Biomedical Sciences |
EDUCATION/PROFESSIONAL EXPERIENCE
Education:
1991- B.S., Biology, Northeast Normal University, China
2004- M.S., Biology, Loyola University Chicago, Chicago, IL
2007-Ph. D., Neuroscience, Loyola University Chicago, Maywood, IL
2008-2014 Postdoctoral Fellow, Michigan State University, East Lansing, MI
Professional Experience:
2017- Present - Assistant Professor, Department of Biomedical Sciences, Quillen College
of Medicine, East Tennessee State University, Johnson City, TN
2014-2017 - Research Assistant Professor, Department of Biomedical Sciences, Quillen
College of Medicine, East Tennessee State University, Johnson City, TN
RESEARCH/TEACHING INTERESTS
1. Neurogenesis and smell function in acute and
chronic olfactory inflammation
2. Astrocytic signaling in Multiple Sclerosis (MS)
3. The role of Amygdala CNTF/Ucn3 in fear
extinction learning
SELECTED PUBLICATIONS
1. Jia C, Lovins C, Malone H, Keasey MP, Hagg T (2022) Female-specific neuroprotection after ischemic stroke by vitronectin-focal adhesion kinase inhibition. Journal of Cerebral Blood Flow & Metabolism, 42(10):1961-1974, PMID 35702047.
2. Jia C*, Drew Gill W, Lovins, C, Brown RW, Hagg T, (2022) Female-specific role of ciliary neurotrophic factor in the medial amygdala in promoting stress responses. Neurobiology of Stress 17:100435, PMID 35146079. * corresponding author.
3. Keasey MP, Lovins C, Jia C, Hagg T, (2022) Liver vitronectin release into the bloodstream increases due to reduced vagal muscarinic signaling after cerebral stroke in female mice. Physiological Report 10(9):e15301, PMID 35531929.
4. Caviness D, Rodriguez-Gil, D, Jia C, (2022) Olfactory dysfunction in SARA-CoV-2 infection: potential benefits of including smell tests in COVID-19 patients. Annals of Otolaryngology and Rhinology, Volume 9, Issue 1.
5. Jia C*, Oliver J, Gilmer D, Lovins, C, Rodriguez-Gil, D, Hagg T, (2020) Inhibition of focal adhesion kinase increases adult olfactory stem cell self-renewal and neuroregeneration through ciliary neurotrophic factor. Stem Cell Research 49:102061, PMID 33130470. * corresponding author.
6. Jia C, Malone, HM, Keasey MP, Lovins C, Elam J, Hagg, T (2020) Blood vitronectin induces detrimental brain IL-6 and correlates with outcomes after stroke only in female mice. Stroke 51(5):1587-95. PMID 32312218.
7. Jia C, Keasey MP, Malone, HM, Lovins C, Hagg, T (2020) Vitronectin mitigates stroke-increased neurogenesis in female mice only and through FAK-regulated IL-6. Experimental Neurology 323:113088. PMID 31678139.
8. Jia C, Keasey MP, Malone, HM, Lovins C, Sante RR, Razskazovskiy V, Hagg, T (2019) Vitronectin from brain pericytes promotes adult forebrain neurogenesis by stimulating CNTF. Experimental Neurology 312:20-32. PMID 30408465.
9. Jia C*, Brown RW, Malone, HM, Burgess, KC, W. Drew Gill, Keasey MP, Hagg, T (2019) Ciliary neurotrophic factor is a key sex-specific regulator of depressive-like behavior in mice. Psychoneuroendocrinology, 100:96-105. PMID 30299260, * corresponding author.
10. Jia C, Keasey MP, Lovins C, Hagg, T (2018) Inhibition of astrocytic FAK-JNK signaling promotes subventricular zone neurogenesis through CNTF. Glia, 66(11):2456-2469. PMID 30500112.
11. Keasey MP, Jia C, Pimentel L, Sante RR, Lovins C, Hagg T, (2018) Blood vitronectin
is a major activator of LIF and pro-inflammatory IL-6 in the brain through integrin-FAK
and uPAR signaling. Journal of Cell Science 131:3. PMID 29222114.
Active Research Funding
NIH R01 DC020528
Role: Principle Investigator
7/1/22 - 6/30/27
Title: Improving olfactory neuroplasticity through FAK/CNTF signaling
The goal is to target FAK signaling in horizontal basal cells and olfactory ensheathing
cells to upregulate CNTF expression, which promotes olfactory neurogenesis and repair
following injury.
The Department of Defense
MS220167
Role: Principle Investigator
9/1/23 - 8/30/25
Title: Inhibition of FAK in astrocytes alleviates MS lesions through LIF and OSM
The goal is to investigate the role of astrocyte FAK on neuroprotection and remyelination
in a mouse Multiple Sclerosis model (EAE).
Laboratory Personnel
Derek Cox, M.S. Research Technician
Makayla Shaw, B.S. Technician
Del Lovins, Technician
Joe Oliver, Pharmacy graduate student