|
Additional Contact Information: Department of Biomedical Sciences |
EDUCATION/PROFESSIONAL EXPERIENCE
B.S. (Chemistry), M.S. (Pharmacology): Philadelphia College of Pharmacy & Science
Ph.D. (Pharmacology): University of Pennsylvania, Philadelphia PA
Dr. H.C : Medical University of Silesia, Katowice, Poland
Research Pharmacologist, Veterans Administration Medical Center, New Orleans, LA,
1971-75
Adjunct Asst. Prof., Pharmacology, Tulane University Medical Center, New Orleans,
LA, 1974-76
Graduate Faculty, Department of Psychology, University of New Orleans, New Orleans,
LA,
1974-77
Assistant Professor of Physiology, Louisiana State University Medical Center, New
Orleans, LA, 1975- 78
Professor of Pharmacology/Biomedical Sciences, Quillen College of Medicine, East Tennessee
State University, 1984 present; Associate Professor, 1978-84
Visiting Professor, Medical University of Silesia in Katowice, Poland, 1997-2003
Editor-in-Chief of the journal Neurotoxicity Research (impact factor, 3.3)
Editor-in-Chief of the 2nd edition of the Handbook of Neurotoxicity - in process (166,000 chapter downloads in 1st edition)
Secretary / Council member, Neurotoxicity Society
co-Organizer, 2021 Neurotoxicity Society meeting in Chile
co-Editor with Dr. Trevor Archer (Univ. Gothenburg) of the book series, Current Topics
in Neurotoxicity
RESEARCH/TEACHING INTERESTS
1. Neuroscience
2. Neurotoxicity
3. Pharmacology
My career interests have focused on highly selective neurotoxins as tools to uncover the ontogeny of monoaminergic systems in brain; also, to study nerve regeneration; to study the reactive elements of one neuronal phenotype subsequent to destruction of an alternate neuronal phenotype; and to characterize the processes of dopamine receptor supersensitivity and serotoninergic receptor sensitivity. These processes are applicable to human Parkinson’s disease, attention deficit hyperactivity disorder (ADHD), schizophrenia, tardive dyskinesia, and recovery from injury.
SELECTED PUBLICATIONS
Kostrzewa RM (Editor-in-Chief) Handbook of Neurotoxicity, 2nd Edition, Springer New
York, Heidelberg, Dordrecht, London, 2021 Completion Date. The 1st Edition, June 2014,
ISBN 978-1-4614-5835-7 (print) had 95 chapters, with 166,000 downloads.
Kostrzewa JP, RM Kostrzewa (2020) p-Chloroamphetamine-enhanced neostriatal dopamine exocytosis in rats neonatally co-lesioned with 6-OHDA and 5,7-DHT: Relevance to Parkinson’s Disease. Neurotoxicity Res. 37(3): 543-552
Kostrzewa RM, Wydra K, Filip M, Crawford C, McDougall SA, Brown RW, Borroto-Escuela DO, Fuxe K and Gainetdinov RR (2018) Dopamine D2 Receptor supersensitivity as a spectrum of neurotoxicity and status in psychiatric disorders. J. Pharmacol. Exp. Ther. 366(3), 519-526
Cox PA, Kostrzewa RM, Guillemin GJ (2018) BMAA and neurodegenerative illness. Neurotoxicity Res. 33(1): 178-183
Kostrzewa RM, Nowak P, Brus R, Brown RW (2016) Perinatal Treatments with the dopamine D2-receptor agonist quinpirole produces permanent D2-receptor supersensitization: a model of schizophrenia. Neurochem. Res. 41(1,2) 183-192
Kostrzewa RM, RA Kostrzewa, JP Kostrzewa (2015) Botulinum neurotoxin: progress in negating its neurotoxicity; and in extending its therapeutic utility via molecular engineering. Peptides 72:80-87
Segura-Aguilar J, RM Kostrzewa (2015) Neurotoxin mechanisms and processes relevant to Parkinson´s Disease: an update. Neurotoxicity Res. 27, 328-354